Sublingual administration allows the rapid introduction of MigraSpray into the bloodstream via the blood vessels located in the highly vascularized mucous membrane under the tongue. This route of absorption bypasses the gastrointestinal tract and requires only small dosages of the active ingredients contained in MigraSpray, which reduces chances of side effects, while simultaneously enhancing the effectiveness of such ingredients.

Although many substances are absorbed sublingually, not all substances are permeable and accessible to the mucous membrane, which may function as a barrier preventing effective diffusion. NatureWell’s micro-spray technology ensures that the sublingual mucous membrane is an ideal site for such absorption.

The administration of sublingual drugs offers improved drug bioavailability and rapid metabolisation allowing more complete absorption and maximizing the benefit to the patient by permitting more precise dosage control. Sublingual drug administration is commonly applied in the field of cardiovascular drugs, steroids, certain barbiturates and enzymes and has been a developing field in the administration of many vitamins and minerals, which are found to be readily and thoroughly absorbed by this method.

Bypassing the gastro-intestinal tract with sublingual delivery not only allows MigraSpray to achieve rapid absorption, reduced degradation and enhanced effectiveness with no reported side effects, but it also serves to avoid unpleasant gastric symptoms in individuals that suffer from a variety of gastrointestinal difficulties such as ulcers, hyperactive gut, celiac disease or compromised digestion.

References
1. Lea, Leilani. “Sublingual Absorption.” Positive Health Complimentary Medicine Magazine.April 21, 2002.

2. Calabrese Ph.D., Edward J. and Linda A. Baldwin, “Developing Insights on the Nature of the Dose-Response Relationship in the Low Dose Zone: Hormesis as a Biological Hypothesis.” Biomedical Therapy Vol. XVI, No. 3 1998: 235-240.