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MigraSpray contains only natural, standardized ingredients and there have been no
reported side effects and no reports of interaction with any over-the-counter or
prescription medications. MigraSpray is safe for treating migraine attacks and safe
for regular daily use to prevent the onset of migraine headache symptoms. There
have been no reports of Medication Overuse Headache
(MOH).
MigraSpray contains the active ingredients feverfew
(its primary ingredient), goldenseal dandelion and larch agaric. Feverfew has been
used for centuries for the treatment of a variety of ailments including headaches,
rheumatic aches, abdominal pain and menstrual cramps. Studies have shown that feverfew
acts as a natural anti-inflammatory controlling the inflammation that results in
cerebral blood vessel dilation, believed to cause or contribute to the symptoms
of migraine headaches.
The herb Feverfew (Pyrethrum Parthenium), also known as Tanacetum parthenium, is
native to Europe, although it is now commonly found in many parts of the world,
including North and South America. Feverfew is a perennial plant and is classified
as a member of the Asteracea or Compositea family, a relative of the daisy.
The active ingredients in Feverfew are sesquiterpene lactones, the primary component
being parthenolide, a phyto-chemical. Studies have shown that parthenolide inhibits
platelet aggregation and the release of serotonin from platelets. Feverfew has also
been shown to inhibit pro-inflammatory prostaglandin synthesis. These anti-inflammatory
properties may control the inflammation that results in cerebral blood vessel dilation,
a cause or contributor to the symptoms of migraine headaches.
Feverfew has been used for centuries and originally became popular with English
herbalists in the middle ages. As the name suggests, feverfew was used as an application
for the treatment of “fevers.” However, the word “fever” at that time referred to
a number of ailments, including rheumatic aches, abdominal pain and headaches.
Over the past two decades medical interest of feverfew has been rekindled in response
to various in-vitro studies as well as the wide spread use of feverfew among the
general public. A number of research groups have formally investigated the clinical
use of the herb for the relief of symptoms of migraine headaches.
Several studies, including one in "The Lancet" and another in "The British Medical
Journal" have demonstrated feverfew’s potential for preventative relief of migraine.
These double-blind placebo studies showed a statistically significant number of
patients reporting a reduction in the number and/or severity of migraine attacks.
Subsequent studies have substantiated the use of feverfew in controlling the symptoms
of migraines.
A study testing the efficacy of using MigraSpray for prevention was conducted in
New York City by Dr. Fred Pescatore, M.D., MPH, Director of the Centers for Integrative
and Complimentary Medicine in New York City and Dallas. Of the patients studied
using MigraSpray on a continual daily basis, approximately 90% had their migraine
headache attacks eliminated.
The efficacy of MigraSpray for treating a migraine attack was also demonstrated
in a randomized, placebo-controlled, double-blind, crossover trial for migraine
headache relief drawn from a general population, reporting migraine headaches. The
strength of this trial includes its draw from a general population, design, outside
review, extremely high safety record, equal baseline characteristics between the
two groups (placebo and product), and statistical significance in all the major
end-point categories. The results of the trial demonstrated that nearly eighty-eight
percent of the patients studied using MigraSpray received some degree of relief
from their migraine headache symptoms within an average of less than 7 minutes.
The results of this study are statistically significant, at a P value of less than
0.01 in all parameters.
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